ADNI data is made available to researchers around the world. As such, there are many active research projects accessing and applying the shared ADNI data. To further encourage Alzheimer’s disease research collaboration, and to help prevent duplicate efforts, the list below shows the specific research focus of the active ADNI investigations. This information is requested annually as a requirement for data access.
|Principal Investigator's Name:||Soheil Shams|
|Proposed Analysis:||For this project we will perform copy number and allelic event profiling (and potentially gene expression analysis) of neurogenetic disorders and perform comparisons of such profiles among different subsets of the data. We will use some clinical information (e.g. gender, survival, etc.) to view differences in different profiles of the samples. BioDiscovery's desktop applications such as Nexus Copy Number and Nexus Expression will be used to for the analyses. We will load in the data along with clinical information and perform copy number analysis with Nexus Copy Number. We will also integrate other data such as expression and miRNA to correlate with the copy number changes. We will use this data, in live presentations and online seminars, to demonstrate how Nexus Copy Number works. Any interesting findings using this data may be published in scientific journals and presented at meetings.|