ADNI data is made available to researchers around the world. As such, there are many active research projects accessing and applying the shared ADNI data. To further encourage Alzheimer’s disease research collaboration, and to help prevent duplicate efforts, the list below shows the specific research focus of the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Christian Habeck |
| Institution: | Columbia Un |
| Department: | Taub Institute (Neurology) |
| Country: | |
| Proposed Analysis: | ----------------------------- For more detailed explanation, see C. Habeck, N. L Foster, R. Perneczky, A. Kurz, P. Alexopoulos, R. A. Koeppe, A. Drzezga, Y. Stern. Multivariate and univariate neuroimaging biomarkers of Alzheimer's disease. NeuroImage 2008; 40: 1503-1515 ------------------------------------------ Comparison of PIB and FDG-PET multivariate and univariate AD-markers - I will derive multivariate and univariate AD-markers from a cross-sectional comparison of PIB/FDG data of control subjects and AD patients (derivation sample) - Diagnostic efficacies of both markers will be tested on a replication data set, using control subjects and AD patients in a replication sample that has no overlap with the derivation sample. The performance metrics will be ROC-curve characteristics - A permutation test using ROC-area differences as a test statistic will determine which image modality (PIB or FDG) and analysis method (univariate/multivariate) has better replication-performance - Correlation of subject expression of all markers with additional clinical variables (MMSE, APOE status, age, etc) will also be performed in replication samples of control subjects, MCI and AD patients |
| Additional Investigators |