ADNI data is made available to researchers around the world. As such, there are many active research projects accessing and applying the shared ADNI data. To further encourage Alzheimer’s disease research collaboration, and to help prevent duplicate efforts, the list below shows the specific research focus of the active ADNI investigations. This information is requested annually as a requirement for data access.
|Principal Investigator's Name:||Darren Gitelman|
|Proposed Analysis:||A recent study has suggested that the brain may exhibit correlations in gray matter density between different brain regions. This may occur because of mutual trophic influences or similar experience-related plasticity (Mechelli, A., Friston, K.J., Frackowiak, R.S., Price, C.J., 2005. Structural covariance in the human cortex. Journal of Neuroscience 25, 8303-8310). This study looked at gray matter correlations across some standard brain regions (Broca?s area, visual cortex, etc.) in normal subjects. We propose an exploratory study to extend this analysis to other brain areas in normal subjects, and patients with Alzheimer's disease or mild cognitive impairment. Brain regions will include hippocampi, anterior and posterior cingulate, parietal cortex, and visual and motor cortex in order to evaluate areas both affected and unaffected by Alzheimer's disease. We hypothesize that anatomical covariances will be disrupted in regions affected by the Alzheimer disease process and that this will correlate with cognitive and/or functional status. T1 anatomic scans from normal controls, AD patients and MCI patients will be analyzed using VBM to look at anatomical covariances across subjects (see Mechelli et al, 2005) for the technique.|