ADNI data is made available to researchers around the world. As such, there are many active research projects accessing and applying the shared ADNI data. To further encourage Alzheimer’s disease research collaboration, and to help prevent duplicate efforts, the list below shows the specific research focus of the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | James O'Donnell |
| Institution: | University Hospitals Case Medical Center |
| Department: | Department of Radiology; Division Nuclear Medicine |
| Country: | |
| Proposed Analysis: | Dear ladies and gentlemen, we would like to assess a prototype of a software for augmenting the reading of imaging cases in dementia by providing reproducible image quantification and by supporting a reader's confidence. The prototype is essentially based on Wenzel, Fabian et al. B-spline-based stereotactical normalization of brain FDG PET scans in suspected neurodegenerative disease: Impact on voxel-based statistical single-subject analysis. Neuroimage 2010; 50:994–1003. Since the publication of this paper, the algorithm was refined and new features were added, amongst others a quantitative assessment of Amyloid depositions. In a first step, we would like to assess the reader's interpretative confidence as well as inter- and intra-reader reliability in Alzheimer disease diagnosis using "computer-aided-diagnosis". Future research will focus on an extension of the software to assess MCI subjects and providing more accurate quantification by enhanced, multi-modality based segmentation. Thank you very much! |
| Additional Investigators | |
| Investigator's Name: | Christian Rubbert |
| Proposed Analysis: | Please see before. |
| Investigator's Name: | José Luís Vercher-Conjero |
| Proposed Analysis: | Please see before. |