ADNI data is made available to researchers around the world. As such, there are many active research projects accessing and applying the shared ADNI data. To further encourage Alzheimer’s disease research collaboration, and to help prevent duplicate efforts, the list below shows the specific research focus of the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Wiesje Flier, van der |
| Institution: | VU Medical University |
| Department: | Alzheimercentrum |
| Country: | |
| Proposed Analysis: | The influence of genetic variants in SORL1 gene on the manifestation of Alzheimer’s disease. In several studies a genetic association between Alzheimer’s disease and SORL1 gene has been found. Multiple SORL1 single nucleotide polymorphisms (SNPs) have been investigated. With the use of data from ADNI and a list of selected SNPs we want to investigate the hypothesis that variants in SORL1 SNPs may influence the manifestation of Alzheimer’s disease in terms of cognitive profile, pattern of atrophy or cerebrovascular disease. We will take into account APOE genotype as potential effect modifier. |
| Additional Investigators | |
| Investigator's Name: | Eva Louwersheimer |
| Proposed Analysis: | The influence of genetic variants in SORL1 gene on the manifestation of Alzheimer’s disease. In several studies a genetic association between Alzheimer’s disease and SORL1 gene has been found. Multiple SORL1 single nucleotide polymorphisms (SNPs) have been investigated. With the use of data from ADNI and a list of selected SNPs we want to investigate the hypothesis that variants in SORL1 SNPs may influence the manifestation of Alzheimer’s disease in terms of cognitive profile, pattern of atrophy or cerebrovascular disease. We will take into account APOE genotype as potential effect modifier. |