ADNI data is made available to researchers around the world. As such, there are many active research projects accessing and applying the shared ADNI data. To further encourage Alzheimer’s disease research collaboration, and to help prevent duplicate efforts, the list below shows the specific research focus of the active ADNI investigations. This information is requested annually as a requirement for data access.
|Principal Investigator's Name:||Hongxing Lei|
|Institution:||Beijing Institute of Genomics, Chinese Academy of Sciences|
|Department:||CAS key lab of Genome Sciences and Information|
|Proposed Analysis:||Since no cure is currently available for Alzheimer’s disease (AD), early diagnosis becomes very important. In our recent work (Sun et al. JAD 2012, 28, 389-402, Liang et al. PLoS One 2012, in press), we have performed comprehensive analysis on all available human brain transcriptome data related to AD and aging and discovered a stepwise breakdown of the cellular machinery during AD progression. We intend to apply these findings to the early diagnosis of AD. Our model will be mainly based on genetic information and blood transcriptome. To come up with a reliable model, we will evaluate the correlation among genetic information, brain imaging information, clinical diagnosis, and other biomarkers provided by ADNI. We anticipate publishing our findings in the near future.|