ADNI data is made available to researchers around the world. As such, there are many active research projects accessing and applying the shared ADNI data. To further encourage Alzheimer’s disease research collaboration, and to help prevent duplicate efforts, the list below shows the specific research focus of the active ADNI investigations. This information is requested annually as a requirement for data access.
|Principal Investigator's Name:||Joanne Conover|
|Institution:||University of Connecticut|
|Department:||Physiology and Neurobiology|
|Proposed Analysis:||Barriers within the brain include the blood brain barrier and a monolayer of ependymal cells that line the ventricle walls of the brain and provide a barrier at the ventricle surface. In the human brain there is aging-related expansion of the ventricles; however, little is known about the capacity of the ependymal monolayer to adapt to increased surface area requirements, while maintaining barrier integrity. Using magnetic resonance imaging (MRI), we aim to determine the spatiotemporal trends in lateral ventricle expansion, and to evaluate the corresponding changes in fluid accumulation along the ventricle wall using FLAIR-MRI. Trends will be evaluated in aging and in Alzheimer's disease.|