ADNI data is made available to researchers around the world. As such, there are many active research projects accessing and applying the shared ADNI data. To further encourage Alzheimer’s disease research collaboration, and to help prevent duplicate efforts, the list below shows the specific research focus of the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | David Alexander Dickie |
| Institution: | The University of Edinburgh |
| Department: | Brain Research Imaging Centre |
| Country: | |
| Proposed Analysis: | Dear ADNI Data Sharing and Publications Committee, We should be most grateful if you would consider our application for access to the Alzheimer’s Disease Neuroimaging Initiative (ADNI) brain image databank. In previous work, using images from our databank and the Open Access Series of Imaging Studies (OASIS) databank, we showed that definition and visualisation of the distribution of normal ageing brain atrophy (proportion of cerebral spinal fluid in total intracranial volume) may improve diagnoses of pathological brain structure (Farrell C, et al. Development and initial testing of normal reference MR images for the brain at ages 65-70 and 75-80 years. Eur Radiol 2009; 19: 177–183). From a recent review (Dickie DA, et al. Do brain image databanks support understanding of normal ageing brain structure? A systematic review. Eur Radiol Accepted pending revisions) it was apparent that the ADNI data may validate these results i.e. by comparing the ADNI subjects to the distribution we previously defined we will indicate whether or not our findings and reference images may be used to classify subjects and improve diagnoses of pathology in the wider ageing population. Further, the processing steps required in this proposed work will also provide a measure of the compatibility among international brain image databanks. We hope that this letter provides a clear focus of our research and look forward to receiving your reply, Yours sincerely David Alexander Dickie, Dr Dominic E. Job, and Professor Joanna M. Wardlaw Brain Research Imaging Centre (BRIC) The University of Edinburgh and the Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration Western General Hospital Crewe Road Edinburgh EH4 2XU United Kingdom |
| Additional Investigators | |
| Investigator's Name: | Dominic Job |
| Proposed Analysis: | Dear ADNI Data Sharing and Publications Committee, We should be most grateful if you would consider our application for access to the Alzheimer’s Disease Neuroimaging Initiative (ADNI) brain image databank. In previous work, using images from our databank and the Open Access Series of Imaging Studies (OASIS) databank, we showed that definition and visualisation of the distribution of normal ageing brain atrophy (proportion of cerebral spinal fluid in total intracranial volume) may improve diagnoses of pathological brain structure (Farrell C, et al. Development and initial testing of normal reference MR images for the brain at ages 65-70 and 75-80 years. Eur Radiol 2009; 19: 177–183). From a recent review (Dickie DA, et al. Do brain image databanks support understanding of normal ageing brain structure? A systematic review. Eur Radiol Accepted pending revisions) it was apparent that the ADNI data may validate these results i.e. by comparing the ADNI subjects to the distribution we previously defined we will indicate whether or not our findings and reference images may be used to classify subjects and improve diagnoses of pathology in the wider ageing population. Further, the processing steps required in this proposed work will also provide a measure of the compatibility among international brain image databanks. We hope that this letter provides a clear focus of our research and look forward to receiving your reply, Yours sincerely David Alexander Dickie, Dr Dominic E. Job, and Professor Joanna M. Wardlaw Brain Research Imaging Centre (BRIC) The University of Edinburgh and the Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration Western General Hospital Crewe Road Edinburgh EH4 2XU United Kingdom |
| Investigator's Name: | Joanna Wardlaw |
| Proposed Analysis: | Dear ADNI Data Sharing and Publications Committee, We should be most grateful if you would consider our application for access to the Alzheimer’s Disease Neuroimaging Initiative (ADNI) brain image databank. In previous work, using images from our databank and the Open Access Series of Imaging Studies (OASIS) databank, we showed that definition and visualisation of the distribution of normal ageing brain atrophy (proportion of cerebral spinal fluid in total intracranial volume) may improve diagnoses of pathological brain structure (Farrell C, et al. Development and initial testing of normal reference MR images for the brain at ages 65-70 and 75-80 years. Eur Radiol 2009; 19: 177–183). From a recent review (Dickie DA, et al. Do brain image databanks support understanding of normal ageing brain structure? A systematic review. Eur Radiol Accepted pending revisions) it was apparent that the ADNI data may validate these results i.e. by comparing the ADNI subjects to the distribution we previously defined we will indicate whether or not our findings and reference images may be used to classify subjects and improve diagnoses of pathology in the wider ageing population. Further, the processing steps required in this proposed work will also provide a measure of the compatibility among international brain image databanks. We hope that this letter provides a clear focus of our research and look forward to receiving your reply, Yours sincerely David Alexander Dickie, Dr Dominic E. Job, and Professor Joanna M. Wardlaw Brain Research Imaging Centre (BRIC) The University of Edinburgh and the Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration Western General Hospital Crewe Road Edinburgh EH4 2XU United Kingdom |