ADNI data is made available to researchers around the world. As such, there are many active research projects accessing and applying the shared ADNI data. To further encourage Alzheimer’s disease research collaboration, and to help prevent duplicate efforts, the list below shows the specific research focus of the active ADNI investigations. This information is requested annually as a requirement for data access.
|Principal Investigator's Name:||Ihab Hajjar|
|Proposed Analysis:||We are proposing to look at the sex-based difference in glucose metabolisms in normal adults. Thisanalysis will be part of the preliminary data section for the proposal. Bleow are the specific aims: AIM 1: To investigate the sex-based differences in bioenergetics measures in the aging brain using 13C-glucose MRS and FDG PET. Our hypotheses are that compared to age-matched men, menopausal women will have significantly lower neuronal TCA cycle rate (13C glucose MRS) and lower cerebral glucose uptake (FDG PET). AIM2: To investigate the sex-based differences in bioenergetics using 13C-glucose MRS and FDG PET in carriers and non-carriers of the APOE*4 allele. Our hypotheses are that APOE*4 carriers will demonstrate significantly lower TCA rates and CMRgl compared to APOE*4 carriers, and that these measures will be more severely reduced in female compared to male APOE*4 carriers. AIM 3: To determine if there are sex-based differences in the relationship between TCA measures and FDG PET in brain regions that show hypometabolism in aging (e.g., anterior cingulate) and in APOE*4 carriers (posterior cingulate/precuneus). Using the ADNI data we would like to compare the mena dn women CMRGL globally in the frontal, cingulate and percuneeus regions in those with available PET data|