ADNI data is made available to researchers around the world. As such, there are many active research projects accessing and applying the shared ADNI data. To further encourage Alzheimer’s disease research collaboration, and to help prevent duplicate efforts, the list below shows the specific research focus of the active ADNI investigations. This information is requested annually as a requirement for data access.
|Principal Investigator's Name:||Linda Liu|
|Institution:||Stanford University School of Medicine|
|Proposed Analysis:||The proposed analyses will leverage the genetic risk for Alzheimer’s Disease (AD) conferred by a specific single nucleotide polymorphism (SNP) in the ApoE gene to glean new insights into AD pathogenesis. The ApoE4 allele is overrepresented in AD and confers ApoE4 carriers substantial risk of subsequent development of AD. However, only some ApoE4 carriers contract AD, and the AD phenotypes of ApoE4 carrier AD patients vary greatly. In other words, there is much AD status- and quality-related variance that ApoE4 does not explain. I am primarily interested in looking at ApoE4 interactions with other SNPs, which could help explain some of that previously unexplained variance. I am interested in examining ApoE-SNP interactions, and other SNP-SNP interactions, that could be associated with increased risk for AD, as well as other AD associated biomarkers and endophenotypes, like performance on neuropsychiatric assessments, conversion from MCI to AD, CNS Tau levels, neurovolumetric measures, and resting state functional connectivity. This project will bridge the often-formidable gab between basic and clinical neuroscience to identify novel genes in linking ApoE to AD.|