ADNI data is made available to researchers around the world. As such, there are many active research projects accessing and applying the shared ADNI data. To further encourage Alzheimer’s disease research collaboration, and to help prevent duplicate efforts, the list below shows the specific research focus of the active ADNI investigations. This information is requested annually as a requirement for data access.
|Principal Investigator's Name:||Jennifer Goldman|
|Proposed Analysis:||The current project investigates the association between structural magnetic resonance imaging (MRI) brain atrophy patterns and cognitive impairment in a cohort of Parkinson’s disease (PD) patients evaluated at Rush University Medical Center by Jennifer Goldman, M.D., M.S. as part of her NIH NINDS K23NS060949 grant and under the mentorship of Leyla deToledo-Morrell, Ph.D. and Christopher Goetz, M.D. The MRI protocol for the PD patients enrolled in the study includes the same scanning sequences/protocol used in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) study for GE 1.5T scanners; permission to use the ADNI imaging protocol has been previously obtained from Michael Weiner, M.D. and Clifford Jack, M.D. and also follows the guidelines on the LONI website for ADNI-MRI methods. In addition, the cognitive battery of tests administered to the PD patients overlaps with many of the tests included the ADNI battery. As such, this application is to request data access to the MRI brain scans and clinical/cognitive data for the 200 normal, healthy controls who are part of ADNI and will serve as age- and education-matched controls for the PD cohort. Data from the ADNI cohort of normal controls will be used in comparisons of cognitive and imaging measures in PD patients to study disease-related changes. Proposed analyses include comparisons of brain atrophy patterns using volumetric techniques (e.g., manual and semi-automated), cortical thickness (e.g., FreeSurfer), and white matter changes in the two cohorts. All ADNI data access guidelines will be followed.|