ADNI data is made available to researchers around the world. As such, there are many active research projects accessing and applying the shared ADNI data. To further encourage Alzheimer’s disease research collaboration, and to help prevent duplicate efforts, the list below shows the specific research focus of the active ADNI investigations. This information is requested annually as a requirement for data access.
|Principal Investigator's Name:||Jonathan Bartlett|
|Institution:||London School of Hygiene and Tropical Medicine|
|Department:||Department of Medical Statistics|
|Proposed Analysis:||In a recent analysis with collaborators at the Dementia Research Centre, Institute of Neurology, London, which has just been published in the Annals of Neurology (DOI: 10.1002/ana.22315), we found a non-linear relationship between whole brain atrophy in the first year following baseline in ADNI and CSF Aβ1-42. As only ~50% of ADNI subjects had CSF, this analysis was restricted to those with CSF available. I have been investigating the development of multiple imputation methods which allow for such non-linear relationships, and would like to use the brain atrophy/Aβ1-42 data from ADNI as an illustrative example. I would prepare a manuscript for a statistical journal, and the analysis of the ADNI data would form the motivating example.|