ADNI data is made available to researchers around the world. As such, there are many active research projects accessing and applying the shared ADNI data. To further encourage Alzheimer’s disease research collaboration, and to help prevent duplicate efforts, the list below shows the specific research focus of the active ADNI investigations. This information is requested annually as a requirement for data access.
|Principal Investigator's Name:||Andrew Reid|
|Institution:||Montreal Neurological Institute|
|Department:||McConnell Brain Imaging Center|
|Proposed Analysis:||Firstly, I intend to utilize structural MRI to obtain cortical thickness measures for all subjects, using the Civet processing pipeline. From these measures I will compile group-wise connectivity matrices, based upon interareal correlations in thickness. Secondly, I will compile group-wise functional connectivity matrices based upon FDG-PET data. I will investigate the relationship between these functional and structural connectivity patterns, both cross-sectionally and longitudinally, to determine any differences between NC, MCI, and AD groups. Thirdly, I will compare these patterns to cognitive and biomarker data, with the intention of associating specific cognitive deficits or longitudinal changes with specific network changes. Finally, I will attempt to determine whether such connectivity changes might be used to aid as markers or surrogate endpoints for clinical trials, and if so what sort of advantages they might confer in terms of statistical power.|