ADNI data is made available to researchers around the world. As such, there are many active research projects accessing and applying the shared ADNI data. To further encourage Alzheimer’s disease research collaboration, and to help prevent duplicate efforts, the list below shows the specific research focus of the active ADNI investigations. This information is requested annually as a requirement for data access.
|Principal Investigator's Name:||Casper Nielsen|
|Institution:||University College London (UCL)|
|Department:||Dementia Research Centre, Institute of Neurology|
|Proposed Analysis:||Brain and ventricular segmentation of T1 MRI scans using the MIDAS semi-automatic segmentation framework (P. A. Freeborough et al; 1997; Interactive algorithms for the segmentation and quantification of 3-D MRI brain scans; Computer Methods and programs in Biomedicine 53; 15-25). Longitudinal analysis of said scans and regions based on absolute volumes and volume change measured using the Boundary Shift Integral (P. A. Freeborough et al; 1997; The Boundary Shift Integral: An Accurate and Robust Measure of Cerebral Volume Changes from Registered Repeat MRI; IEEE Transactions on Medical Imaging 16(5); 623-629) and the K-Means Normalisation Boundary Shift Integral (K. K. Leung et al; 2010; Robust atrophy rate measurement in Alzheimer's disease using multi-site serial MRI: Tissue-specific intensity normalization and parameter selection; Neurology 50; 516-523). Automated region definition and regional atrophy measures including hippocampi. Please note: the DRC have been working with ADNI data for 3+ years. Recently our account access was revoked because we didn't submit an annual data use update. No request for an update had been received. The account was registered to the e-mail address firstname.lastname@example.org. We requested for access to be reinstated, but were told that the only way was to submit a new application. We have been assured that by registering using the same e-mail address, our download history and all other data associated with the old account will be available again.|