ADNI data is made available to researchers around the world. As such, there are many active research projects accessing and applying the shared ADNI data. To further encourage Alzheimer’s disease research collaboration, and to help prevent duplicate efforts, the list below shows the specific research focus of the active ADNI investigations. This information is requested annually as a requirement for data access.
|Principal Investigator's Name:||Thaddeus Haight|
|Department:||Helen Wills Neuroscience Institute|
|Proposed Analysis:||These proposed analyses will be conducted as part of my postdoctoral appointment with Dr. William Jagust, who serves as co-PI on ADNI. Objective of these analyses will be to examine the relationship of amyloid deposition, as measured by PIB-PET, CSF AB, and F18 PET, and hypometabolism, as measured by FDG-PET, to the pathogenesis of Alzheimer's Disease (AD). These analyses will investigate whether these biomarkers reflect separate processes, or whether these biomarkers share a common pathway to AD --e.g., they represents surrogates of metabolic dysfunction that underlies the disease process. In addition, the analyses will investigate how regional differences in levels of these biomarkers are associated with patterns of decline---e.g., accelerated decline in AD pathogenesis. The analyses will make use of the longitundinal data that are available from ADNI to investigate these relationships, and apply methodological tools to analyse pathways of interest--i.e., direct and indirect pathways--to examine the potential mechanisms that contribute to AD.|
|Investigator's Name:||William Jagust|
|Proposed Analysis:||Dr. Jagust will work Dr. Haight-his postdoctoral appointee--on the analyses proposed by Dr. Haight.|