ADNI data is made available to researchers around the world. As such, there are many active research projects accessing and applying the shared ADNI data. To further encourage Alzheimer’s disease research collaboration, and to help prevent duplicate efforts, the list below shows the specific research focus of the active ADNI investigations. This information is requested annually as a requirement for data access.
|Principal Investigator's Name:||Davangere Devanand|
|Proposed Analysis:||In a separate sample of MCI patients and healthy comparison subjects, we have published on a predictor model of conversion from MCI to AD in which the strongest predictors were measures of verbal memory, daily functioning, hippocampal atrophy, entorhinal cortex atrophy, and odor identification deficits, and a strong predictor model was developed (Devanand et al, Neurology 68:828-36, 2007; Devanand et al, Biological Psychiatry 64:871-879, 2008). Since ADNI has either similar or identical variables with the exception of odor identification deficits, we are interested in examining these predictors in the ADNI dataset in predicting MCI conversion to AD and to validate our independently obtained findings. Objective 1. To examine the predictive utility of baseline measures of verbal memory (AVLT, Logical Memory), function (FAQ), hippocampal volume, entorhinal cortex volume, and FDG PET (parietal and temporal metabolism deficits) in predicting MCI conversion to AD at the 2 year and 3 year follow-up time-points. Objective 2. To compare and validate the predictive accuracy (sensitivity, specificity, positive and negative predictive values) of these individual measures, and in combination, against our previously published measures of predictive accuracy for conversion of MCI to AD. Analytic methods will rely primarily on logistic regression and survival analysis, which we used in our publications on this topic. Investigators: Drs. D.P. Devanand, Patrick Brown, Gregory Pelton, Yaakov Stern (ADNI site PI at Columbia University), Xinhua Liu (statistician).|