ADNI data is made available to researchers around the world. As such, there are many active research projects accessing and applying the shared ADNI data. To further encourage Alzheimer’s disease research collaboration, and to help prevent duplicate efforts, the list below shows the specific research focus of the active ADNI investigations. This information is requested annually as a requirement for data access.
|Principal Investigator's Name:||Leyla deToledo-Morrell|
|Institution:||Rush University Medical Center|
|Proposed Analysis:||Previous work from our laboratory has indicated that the parahippocampal white matter region that includes the perforant path shows atrophy in people who are at risk of developing Alzheimerâ??s disease (AD) compared to age-matched controls without cognitive impairment (Stoub et al., 2006). Such structural alterations in the parahippocampal white matter may be a consequence of cell loss in the entorhinal cortex and may degrade multimodal sensory information to the hippocampus, thus exacerbating the memory impairment. We would like to perform analyses similar to our earlier work (with voxel based morphometry and volumetry) using the ADNI Control and MCI cohorts and relate parahippocampal white matter changes to a) declarative memory scores and b) the extent of atrophy in the entorhinal cortex. Since the entorhinal cortex and the parahippocampal white matter region are affected very early in the disease process of AD, using longitudinal clinical data, we would also like to examine if alterations in the parahippocampal white matter in the region of the perforant path are predictive of cognitive decline or of conversion to Alzheimerâ??s disease. References: S Stoub TR, deToledo-Morrell L, Stebbins GT, Leurgans S, Bennett DA, Shah RC. Hippocampal disconnection contributes to the memory dysfunction in individuals at risk of Alzheimerâ??s disease. Proceedings of the National Academy of Sciences 2006;103:10041-10045.|
|Investigator's Name:||Travis Stoub|