The clinical data set may be downloaded by authorized users only.
Where can I find a copy of the cognitive assessment worksheets (ADAS-Cog, etc.) used to score patients at each visit?
There are three versions of the ADNI cognitive assessments for ADNI. Unfortunately we are unable to release the worksheets. Refer to Cognitive Assessment section of the ADNI General Procedures Manual for information regarding cognitive assessments at visits other than BL, M6 and M12.
Item level scores and two versions of total scores are available in the adni_adasscores file. TOTAL11 corresponds to the total score on the 11-item ADAS (items 4 and 13 omitted) and TOTALMOD corresponds to the total score on the modified 13-item ADAS (item 13 omitted).
|Rosen et al., 1984 (modified Mohs, 1994)*||Petersen et al., 2005|
|4||Delayed Word Recall||–||10|
* unpublished manual
Raw item level responses are available in the adni_adas file.
How can I find images that correspond with the numeric summary files (adni_strokesum, adni_ucbpet, adni_ucsdvol, adni_ucsfsntvol, etc)?
You may find the images in the following ways:
- The csv files provided in the clinical data downloads contain the subject ID, visit code and unique LONI image ID for each value reported.
- Use these elements to searchthe IDA. Specifically, enter the subject ID, choose the appropriate visit code and select processed data (radio button).
- On the query results page, hold the mouse over the series description to determine the LONI image ID (the URL shown at the bottom of the web browser contains the imageId that matches that in the csv files).
Not at this time.
Diagnosis conversion information is captured in the “Diagnostic Summary” data set which may be downloaded from within the ADNI Data Archive.
Not all clinical data files contain date of the exam (EXAMDATE) especially for ADNIGO/2. You can extract EXAMDATE from the registry table (REGISTRY.csv) using RID, Phase, and VISCODE.
The data dictionary for clinical data is located on the LONI Image Data Archive (IDA). Enter your username and password, go to Download, then Study Data. When you click on Study Info, you will see Data Dictionary [ADNI1,GO,2] (DATADIC.csv). Some files will have their own data dictionary, particularly those related to some of the biospecimens and the imaging numeric summaries.
ADNI2 VISCODE is different from ADNI1 and ADNIGO. How can I make use of visit codes across the three phases of ADNI?
ADCS created a new visit code variable called “VISCODE2” (sc, scmri, bl, m06, etc.) for ADNI2. (Please see ADNI 2 Visit Codes Assignment Methods (PDF) on LONI). For longitudinal models, it is still recommended that people use the actual time since the initial visit (using EXAMDATE) rather than the visit code to determine time, because there is variability in when the visits occurred.
Early MCI (eMCI) subjects were added to the recruitment in ADNIGO and ADNI2 to get some MCI subjects earlier in the course of their impairment. These individuals still have a diagnosis of MCI, but have less memory impairment than the MCI subjects recruited during ADNI1 (Late MCI or lMCI). ADNIGO and ADNI2 will continue to recruit subjects in the lMCI category. You can identify the eMCI subjects by merging the ARM table with the Diagnostic Summary table and identifying those with ARM==10 & DXCHANGE==2.
Missing data is coded with -1 and -4. Generally, -4 is used for “passively” missing or not applicable (e.g. item is not collected at a particular visit), and -1 is used for data which is confirmed missing at point of data entry.
This is mostly answered on the image-data page. Further explanation could be — (ADNI 1): Subjects who were randomized into the 3T scanner group had a 1.5T screening scan as part of the study inclusion/exclusion screening. Those subjects meeting inclusion criteria had a 3T scan at the Baseline visit. A chart detailing imaging visits is show in the Image Data section.
The study design specifies the visits required for each research group (Control, eMCI, MCI, AD). You can review the study schedule in the procedures manual for ADNI1, ADNI GO, or ADNI2 or download the study schedule. These documents can be found on the Documents: Procedures, Protocols, and Manuals webpage.
Which column in all the CSV files is the ADNI subject ID number correspondent to the “Subject ID” number in the LONI-ADNI database, the “ID” column or the “RID” column?
In the ADNI subject IDs of the form 123_S_5678, the last 4 digits correspond to the roster ID (RID) which you see in every CSV file. You can also refer to the adni_roster table which lists RIDs and their associated PTIDs (of the form 123_S_5678).
The NV (“No Visit” or “Not Yet Determined”) visit code is applied when we receive scan QC data (e.g. mrinclusio) before we receive scan information sheets (e.g. mrimeta). In these instances, we do not yet know with which visit the scan QC data is associated.
Occasionally scan QC and scan information records which should be linked are not linkable because of discrepant data (e.g. exam dates do not match). The NV data code will be used in these cases as well, until the discrepancies are corrected.
The Alzheimer’s Disease Assessment Scale was devised to evaluate cognitive impairment in the assessment of Alzheimer’s disease. ADAS-Cog is recommended for second stage or more detailed assessments and/or for particular research evaluations rather than for applications in routine care settings.
The screening visit consists of a subset of the planned assessments (neuropsychological testing, imaging, etc.) sufficient to evaluate the inclusion/exclusion criteria for each potential participant. Once a participant passed screening, the baseline assessment was conducted in which additional neuropsychological testing, imaging, and fluid samples were taken. The diagnosis at the screening diagnosis was used to randomize individuals to an arm of the ADNI-1 study (1.5T only, 1.5T + 3T, 1.5T + FDG-PET), but the diagnosis from the baseline visit is considered more accurate. For most individuals, the two diagnoses are the same, but the diagnosis did change for a handful of subjects.
You can extract the baseline diagnosis from LONI Download Study Data > Diagnosis > Diagnosis Summary [ADNI1, GO, 2] (DXSUM_PDXCONV_ADNIALL.csv). ADNI1 baseline diagnosis can be obtained using the “DXCURREN” variable at VISCODE==”bl,” and ADNIGO/2 baseline diagnoses can be obtained using the “DXCHANGE” variable.
FreeSurfer can measure volume of cortical or subcortical structures and compute cortical thicknesses using cross-sectional and longitudinal processing. Longitudinal processing creates within a subject template and initializes each time point with the template to reduce individual variability. The ADNI1 images were processed using both methods, while currently, ADNIGO/ADNI2 images have only been processed using cross-sectional FreeSurfer. If the researcher is interested in baseline values and their association with some longitudinal or cross-sectional outcome, we recommend using cross-sectional FreeSurfer values. If interest lies in longitudinal change in the volumes or cortical thicknesses, the longitudinal version of FreeSurfer is recommended (when restricting to ADNI1 subjects).
Specimens from the same subject at the same time point will have slightly different test values if they are tested at different times. To minimize differences due to different assays, when a new batch of samples is run from later visits, samples from earlier visits are also included. Therefore, each biomarker file contains values from all samples run in the same batch and researchers should only use values within the same file.
You can download the document here. More examples with sample code with method paper will be posted on LONI in the future.
Using “REGISTRY.csv,” we have 822 subjects with initial screening (VISCODE == ‘sc’), but only 819 subjects had baseline visit conducted (VISCODE == ‘bl’ and RGCONDCT == 1 (RGCONDCT: Was this visit conducted? 1=Yes, 0=No)). Three people were deemed ineligible after the screening visit and were therefore not continued on to the baseline visit. The 819 that had a baseline visit are considered the official ADNI1 sample.