One of the goals of ADNI is the collection of biospecimens, including blood, urine, and cerebrospinal fluid (CSF) from participants. Interested investigators, whether associated with an ADNI site or not, are encouraged to apply for use of this limited resource. However, use of ADNI samples for technology development or comparisons among different technologies is not recommended for well-established analysis unless there is preliminary data showing clearly superior performance.
Additionally, several analyses results performed by the ADNI Biomarker Core will be available in the Data Archive as follows:
- Homocysteine
- Species of isoprostanes
- CSF tau, sAPPβ levels, BACE levels, and enzyme activity
- Plasma Aβ 40 and Aβ 42
- Other promising CSF and plasma based on ongoing multiplex immunoassay studies and mass spectrometry MRM studies
For information about access to biospecimen samples, or to apply, visit the ADNI-info website. Go to the biomarker analysis webpage to read the methodology documents provided by the respective labs.
ADNI 1 Biospecimen Collection
| All Participants: | Urine | all visits |
| Plasma from Blood | all visits | |
| Serum from Blood | all visits | |
| CSF | baseline and month 12 | |
| Blood for NCRAD | baseline | |
| Blood for APOE | screening | |
| Cell Immortalization | baseline |
ADNI GO Biospecimen Collection
| EMCI Participants: | CSF | screening |
| Plasma from Blood | all visits | |
| Serum from Blood | all visits | |
| APOE/GWAS | baseline | |
| Cell Immortalization | baseline | |
| ADNI 1 Continuing Participants: | RNA | |
| GWAS |
ADNI 2 Biospecimen Collection
| New Controls, EMCI and LMCI Participants: | CSF | baseline and every two years |
| Buffy Coat | all visits | |
| Plasma from Blood | all visits | |
| Serum from Blood | all visits | |
| RNA | baseline, then yearly | |
| APOE/GWAS | baseline | |
| Cell Immortalization | baseline | |
| New AD Participants: | CSF | baseline and Month 24 |
| Buffy Coat | all visits | |
| Plasma from Blood | all visits | |
| Serum from Blood | all visits | |
| RNA | baseline, Months 12 and 24 | |
| APOE/GWAS | baseline | |
| Cell Immortalization | baseline | |
| ADNI 1/GO Continuing Participants: | CSF | baseline, then every two years |
| Buffy Coat | baseline, then yearly | |
| Plasma from Blood | baseline, then yearly | |
| Serum from Blood | baseline, then yearly | |
| RNA | baseline, then yearly | |
| GWAS | baseline if not obtained in ADNI GO |