ADNI: progress report and future plans.“The Alzheimer’s Disease Neuroimaging Initiative (ADNI) beginning in October 2004, is a 6-year research project that studies changes of cognition, function, brain structure and function, and biomarkers in elderly controls, subjects with mild cognitive impairment, and subjects with Alzheimer’s disease (AD). A major goal is to determine and validate MRI, PET images, and cerebrospinal fluid [...] Continue reading...Update on the Biomarker Core of ADNI subjectsFriday, May 21, 2010 Comments Off “Here, we review progress by the Penn Biomarker Core in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) toward developing a pathological cerebrospinal fluid (CSF) and plasma biomarker signature for mild Alzheimer’s disease (AD) as well as a biomarker profile that predicts conversion of mild cognitive impairment (MCI) and/or normal control subjects to AD.” Authors: Trojanowski JQ, [...] Continue reading...Clinical Core of ADNI: progress and plansFriday, May 21, 2010 Comments Off “The Clinical Core of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) has provided clinical, operational, and data management support to ADNI since its inception. This article reviews the activities and accomplishments of the core in support of ADNI aims.” Authors: Aisen PS, Petersen RC, Donohue MC, Gamst A, Raman R, Thomas RG, Walter S, Trojanowski JQ, [...] Continue reading...ADNI biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans.Thursday, May 20, 2010 Comments Off Abstract: The role of the Alzheimer’s Disease Neuroimaging Initiative Genetics Core is to facilitate the investigation of genetic influences on disease onset and trajectory as reflected in structural, functional, and molecular imaging changes; fluid biomarkers; and cognitive status. Major goals include (1) blood sample processing, genotyping, and dissemination, (2) genome-wide association studies (GWAS) of longitudinal phenotypic [...] Continue reading...Update on the magnetic resonance imaging core of ADNIMonday, May 10, 2010 Comments Off “Functions of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) magnetic resonance imaging (MRI) core fall into three categories: (1) those of the central MRI core laboratory at Mayo Clinic, Rochester, Minnesota, needed to generate high quality MRI data in all subjects at each time point; (2) those of the funded ADNI MRI core imaging analysis groups [...] Continue reading...Summary of dates of CSF Biomarker AnalysisWednesday, May 27, 2009 Comments Off Below is a brief summary of dates of CSF biomarker analyses run as batches of samples using the Luminex xMAP platform and Innogenetics INNO-BIA AlzBio3? immunoassay reagents. Normalization of CSF biomarker data between results of 2007 and 2008 have been obtained using a statistical approach, resulting in a procedure to maintain lot-to-lot consistency within clinical [...] Continue reading...Processing Sites UpdatesSaturday, November 1, 2008 Comments Off This is the latest update for processing sites that addresses which scan to use if the site did two scans for a particular timepoint. Click here to download the Excel Spreadsheet Table Continue reading...Scaled 2 UploadsWednesday, October 1, 2008 Comments Off As of 10/01/2008 pre-processed files uploaded to LONI from Mayo may be labeled as either *_scaled or *_scaled_2. Scaled_2 files were rescaled by disabling the scaling on the axis or axes for which the phantom scaling may be unreliable. This occurred in two situations. One, replacing the phantom results in unreliable across time scaling in [...] Continue reading...ADNI: MRI MethodsMonday, April 21, 2008 Comments Off “Magnetic resonance imaging (MRI), (18F)-fluorodeoxyglucose positron emission tomography (FDG PET), urine serum, and cerebrospinal fluid (CSF) biomarkers, as well as clinical/psychometric assessments are acquired at multiple time points. All data will be cross-linked and made available to the general scientific community. The purpose of this report is to describe the MRI methods employed in ADNI. [...] Continue reading... |
Friday, May 21, 2010
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